Does cardiovascular specific 11b-HSD1 deletion reproduce the beneficial effects of global 11b-HSD1 deficiency in the healing myocardial infarct?
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Inhibition of 11b-HSD1 by tetracyclic triterpenoids from Euphorbia kansui.
The roots of Euphorbia kansui are considered an important traditional folk medicine. In this study the ethanol extracts of E. kansui were investigated. A new tetracyclic triterpenoid, euphane-3b,20-dihydroxy-24-ene, in addition to five known triterpenoids with euphane skeletons were isolated. Their structures were elucidated on the basis of physical and spectral techniques (1D-, 2D-NMR and MS, ...
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The activity of the enzyme 11b-hydroxysteroid dehydrogenase type 1 (11b-HSD1), which converts inactive cortisone (11-dehydrocorticosterone (11-DHC)) (in mice) into the active glucocorticoid (GC) cortisol (corticosterone in mice), can amplify tissue GC exposure. Elevated TNFa is a common feature in a range of inflammatory disorders and is detrimental to muscle function in diseases such as rheuma...
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Recent trials show salicylates improve glycemic control in type 2 diabetes, but the mechanism is poorly understood. Expression of the glucocorticoid-generating enzyme 11b-hydroxysteroid dehydrogenase type 1 (11b-HSD1) in adipose tissue is increased in vitro by proinflammatory cytokines and upregulated in obesity. 11b-HSD1 inhibition enhances insulin sensitivity. We hypothesized that salicylates...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2013
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/eht310.p5688